• Triptolide: Mechanisms and Applications in Cancer and Imm...

  2025-09-22

  Explore the multifaceted mechanisms of Triptolide, a potent IL-2/MMP-3/MMP7/MMP19 inhibitor, and its implications for cancer and rheumatoid arthritis research. This article delves into its impact on transcriptional regulation, apoptosis, and recent advances in developmental biology.

• Cy5-UTP in In Vitro RNA Labeling: Illuminating Phase Sepa...

  2025-09-19

  Explore the utility of Cy5-UTP (Cyanine 5-uridine triphosphate) as a fluorescently labeled UTP for RNA labeling, with a focus on its unique applications in dissecting RNA-protein phase separation via in vitro transcription RNA labeling and advanced fluorescence techniques.

• X-press Tag Peptide: Enhancing Epitope-Based Protein Puri...

  2025-09-18

  Explore the rigorous applications of X-press Tag Peptide in recombinant protein purification, focusing on its N-terminal leader peptide design, compatibility with ProBond resin, and implications for post-translational modification studies. This article offers a scientific perspective on optimizing experimental workflows using this advanced protein purification tag peptide.

• Aurora B is also known

  2025-04-21

  

  Aurora-B is also known as chromosomal passenger protein and localizes at the chromosome arms and at centromeres during prophase. As cell cycle continues, Aurora-B moves towards the inner centromere region followed by the central spindle and cortex during HotStart™ 2X Green qPCR Master Mix and final

• Cell Counting Kit-8 (CCK-8) We have recently reported a

  2025-04-21

  

  We have recently reported a regulatory effect of quercetin on the AChE activity in the brainstem during the demyelination and remyelination process [17]. It has also been observed that there is a protective effect on lipid peroxidation and worsening of motor functions caused by loss of myelin in the

• Among the most important Ca regulatory mechanisms are the

  2025-04-19

  

  Among the most important Ca regulatory mechanisms are the Plasma Membrane Calcium ATPase (PMCA) and Sarcoplasmic Reticulum Calcium ATPase (SERCA). These pumps belong to the family of P-ATPases, which share the formation of an acid-stable phosphorylated intermediate as part of their reaction cycle. P

• Recent findings imply that proper Na K ATPase function

  2025-04-19

  

  Recent findings imply, that proper Na+/K+-ATPase function is crucial for unimpaired development of the vertebrate heart. Targeted knockout of Na+/K+-ATPase α1 in mice led to early embryonic lethality whereas heterozygous knockout mice displayed severe hypocontractile hearts [52]. Pharmacological inh

• In this paper we described

  2025-04-18

  

  In this paper, we described synthesis, biological evaluation and docking study of 3-aroyl-1-(4-sulfamoylphenyl)thiourea derivatives 4a–o as 15-lipoxygenase inhibitors. Results and discussion Conclusion We designed and synthesized a novel of thiourea derivatives containing phenylsulfonamide mo

• br Materials and Methods br Results br Discussion HETE

  2025-04-18

  

  Materials and Methods Results Discussion 15-HETE is a predominant eicosanoid in pulmonary vascular remodeling, and it could promote hypoxia-induced PAH via its involvement in the regulation of proliferation and cell cycle progression in PASMCs. To understand its role in HPH, we have previou

• br Extracellular domain architecture The extracellular regio

  2025-04-16

  

  Extracellular domain architecture The extracellular region of GABAB receptor exists in a heterodimeric configuration regardless of interactions within the rest of the protein (Geng et al., 2012, Liu et al., 2004, Nomura et al., 2008). The extracellular domains of the GABAB1 and GABAB2 subunits ar

• Findings of the present study provide a molecular mechanism

  2025-04-16

  

  Findings of the present study provide a molecular mechanism for the elevated ASK1 expression in obesity and how it may be functionally linked to whole-body insulin resistance. The role our findings assign to increased E2F1 in upregulating ASK1 parallels the capacity of this transcription factor to r

• br Experimental section br Acknowledgements br Introduction

  2025-04-16

  

  Experimental section Acknowledgements Introduction DJ-1 is a highly conserved, homodimeric protein that was originally cloned as an oncogene capable of transforming EZ Cap™ Cy5 EGFP mRNA (5-moUTP) in cooperation with activated ras[1]. DJ-1 is over-expressed in multiple tumor types and is po

• Cell Counting Kit-8 (CCK-8) The potent inhibition of aromata

  2025-04-15

  

  The potent inhibition of aromatase by ziram indeed caused the lower estradiol production in JEG-3 cells (Fig. 4), confirming that ziram can penetrate the cell membrane to get into the cells to act. However, the treatment of ziram did not lower progesterone production in JEG-3 cells (Fig. 4), indicat

• Therefore the rational design of target compounds is based

  2025-04-15

  

  Therefore, the rational design of target compounds is based on the hybrid of attractive phenotypic bis-indole (5, Fig. 1) and sulfonamide moieties, in which the indole core might anticipate in hydrophobic interaction, and the functionality of sulfonamide group may involve in H-bonding with the site

• Functional implications notwithstanding the intermolecular c

  2025-04-14

  

  Functional implications notwithstanding, the intermolecular contact appears to shield the Y361 side chain (Fig. 3) from being accessible for regulation by phosphorylation/dephosphorylation as has been proposed [18,19]. It is, therefore, likely that Src kinase and PTP1B phosphatase bind to an AROM mo

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