• Our finding that Eng plays a significant role in the

  2018-10-29

  

  Our finding that Eng plays a significant role in the EC specification is consistent with the published data that support a role of Eng in vascular development (ten Dijke and Arthur, 2007) and angiogenesis (ten Dijke et al., 2008). It is also consistent with the recent finding that ERG1 induces Eng e

• br Results br Discussion Controlling

  2018-10-29

  

  Results Discussion Controlling the chromosome stability of hESCs and their derivatives remains a fundamental challenge in trials of hESC derivative-based cell therapy. In 2004, Andrew and co-workers reported that chromosomal instability during extensive hESC expansion was due to the order Phen

• In this study we demonstrated that

  2018-10-29

  

  In this study, we demonstrated that astrocytes exposed to ACM undergo de-differentiation to multipotent NSPCs which can re-differentiate into neurons, astrocytes, and oligodentrocytes. Whereas blockade of Shh biological functions in ACM does not result in astrocyte de-differentiation to multipotent

• In the context of the above studies and several others

  2018-10-29

  

  In the context of the above studies and several others PCs are not in all instances dispensable and here the data support an important role of PC in the integrity of the ISC niche. Specifically here the observations indicate a direct dependence of PC on CSF-1R signaling via locally presented CSF-1.

• br Conclusion Our results demonstrate that the GAG mimetic O

  2018-10-26

  

  Conclusion Our results demonstrate that the GAG mimetic [OTR4131] is able to enhance the critical human ECFC colony formation frequency, required to improve the amplification of ECFC, and to promote cell properties such as cell adhesion, migration and self-renewal. Moreover, [OTR4131] is able to

• Wnt-C59 Although adult CMs have very limited

  2018-10-26

  

  Although adult CMs have very limited proliferative capacity, it has been suggested that a small population of these cells in regions adjacent to a myocardial infarct, retain the ability to divide (Kajstura et al., 1998; Beltrami et al., 2001). Thus, enhancing their proliferation may augment repair i

• Early studies demonstrated that primitive cells are

  2018-10-26

  

  Early studies demonstrated that primitive Sephin1 are readily converted into iPSCs (Kim et al., 2008; Kleger et al., 2012; Tsai et al., 2011). Thus, we expected that Lgr5+ cells would be susceptible to reprogramming. Unexpectedly, Lgr5+ cells from HFs and MEFs showed more resistance to early reprog

• As part of the endodermal

  2018-10-26

  

  As part of the endodermal lineage, the gallbladder and ventral pancreas both derive from pancreatobiliary progenitors (Spence et al., 2009). The gallbladder is a dispensable organ and can be easily accessed through a minimally invasive laparoscopic procedure. Our previous work demonstrated that mous

• Our analysis revealed that mTOR inhibitors added alone to

  2018-10-26

  

  Our analysis revealed that mTOR inhibitors added alone to SF-defined medium can induce mesendoderm, and our follow-up studies confirmed that rapamycin enhances the formation of HE and blood progenitors. Ten-point dose curves revealed a bimodal effect where rapamycin at low concentrations mildly enha

• The ability to use cell surface

  2018-10-26

  

  The ability to use cell-surface proteins to specifically sort iPSC-derived hepatocyte-like cells is currently limited. The liver-specific cell-surface protein ASGR1 has been used to sort human ESC- and iPSC-derived hepatocyte-like cells (Basma et al., 2009; Peters et al., 2016). These studies demons

• Much of our knowledge on

  2018-10-26

  

  Much of our knowledge on DS comes from the documentation of symptoms in patients and analysis of mouse models. Although the contribution of both sources has been crucial in gaining a better understanding of the syndrome, the molecular pathways leading to the development of DS are still largely unkno

• Global gene expression of RB null teratomas

  2018-10-26

  

  Global gene expression of RB1-null teratomas revealed an upregulation of neural-related genes and a depleted expression of epidermal tissue-related genes. As both the nervous system and the epidermis originate from the ectoderm, these results suggest that the RB1 ablation could alter early ectoderma

• In a comparative perspective life

  2018-10-26

  

  In a comparative perspective, life expectancy is high in Sweden, meaning that even a mother who gives birth at the very advanced age of 50 would be overwhelmingly likely to still be alive when her child is aged 19. Over 80% of women born in Sweden in the 1940 cohort were still alive by age 70 (Stati

• Grau looks beyond this and affirms

  2018-10-26

  

  Grau (2012) looks beyond this and affirms that Spanish universities are not within the actual political priorities of policy makers, and that one of the purposes of the European Commission is for Spanish universities to implement tools of strategic management to become more competitive and responsib

• gap junctions br Theoretical foundation of the study br

  2018-10-26

  

  Theoretical foundation of the study Methodology A Web-based survey was distributed to 3060 international and/or general manager in charge of the firm\'s foreign business activity of Spanish exporting firms in the food sector, beverage sector, consumer goods, raw materials, industrial products

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