• In mammals ribonucleotide reductase RNR is a unique enzyme t

  2019-07-02

  

  In mammals, ribonucleotide reductase (RNR) is a unique enzyme that catalyzes the rate-limiting step of de novo synthesis of deoxyribonucleoside triphosphates (dNTPs).7, 8 Mammalian RNR consists of two homodimer subunits: the large catalytic dimer RRM1 and the small regulatory dimer RRM2 or RRM2B. An

• One possible pitfall of using EPAC activators in the

  2019-07-02

  

  One possible pitfall of using EPAC2 activators in the treatment of T2DM is their potential to increase glucagon levels. As discussed previously, although the ability of EPAC2 to increase glucagon expression and production is controversial, several studies show that this protein increases Gcg mRNA le

• Since the interaction between the E and E is

  2019-07-02

  

  Since the interaction between the E2 and E3 is weak and transient, it has been difficult to identify novel interactions between specific E2/E3 complexes [59], [64]. Here we used a modified bait consisting of the Mulan RING domain fused to one of the four E2s isolated in our screen and expressed in y

• sodium butyrate br In the past decade Brazil has achieved co

  2019-07-01

  

  In the past decade, Brazil has achieved considerable progress in malaria control, with 140 000 cases reported in 2015, the lowest numbers since 1980. Part of this success has been attributed to the establishment of a large network of around 3000 diagnostic and treatment units for malaria. A remark

• br Methods br Results br Discussion

  2019-07-01

  

  Methods Results Discussion Conclusion Conflict of interest Introduction Placement of the left ventricular (LV) pacing lead in a tributary of the coronary sinus (CS) is one of the most challenging technical aspects of cardiac resynchronization therapy (CRT) device implantation. Fail

• br Methods As we were not

  2019-07-01

  

  Methods As we were not privy to the median year of enrolment, for all selected studies, the mean enrolment year ([start of enrolment+end of enrolment]/2) was calculated. If these dates were unavailable, the corresponding authors or sponsoring companies were contacted. When all methods to gather t

• br Clinical material br Discussion TLI is

  2019-07-01

  

  Clinical material Discussion TLI is regarded as a well-tolerated, simple procedure with few acute or late clinical sequelae reported. However, pulmonary irradiation as a therapeutic modality for metastatic bone sarcomas is, although introduced 30 years ago, insufficiently evaluated to clearly

• The animal model described here is also expected to lead

  2019-07-01

  

  The animal model described here is also expected to lead us to design mechanism-based therapeutic interventions for bone metastases of NB. In this context, it is notable that the selective COX-2 inhibitor NS-398, which is known to selectively inhibit COX-2 without affecting COX-1 activity [30], inhi

• Preclinical studies have shown that

  2019-07-01

  

  Preclinical studies have shown that adipocytes and MSCs play an important role in migration and dissemination of cancer Anisodamine [55,56]. Concerning osteosarcoma, one publication has reported that human MSCs injected through the caudal vein of mice bearing Saos-2- induced an increase in tumor vo

• Despu s de marcharse de la India Paz publica

  2019-07-01

  

  Después de marcharse de la India Paz publica , una obra ensayística que sirve como continuación de y comentario sobre la revuelta de los estudiantes mexicanos que precedió ARCA la masacre. En este libro Paz postula que la corrupción del lenguaje es la primera señal de un problema grave a nivel socia

• We did not identify age as a major factor shaping

  2019-07-01

  

  We did not identify age as a major factor shaping continuing HCV transmission and future seroprevalence. With every blood-borne disease, these epidemiological variables depend on how frequently individuals undergo medical procedures and the risk of acquiring HCV in each case. In our study, we used d

• Estimates of life expectancy are

  2019-07-01

  

  Estimates of life expectancy are of obvious importance to people with HIV-1, and are essential to monitor and predict the progress of the HIV/AIDS epidemic and to plan health services. The Rwandan study reported by Sabin Nsanzimana and colleagues in is the first from sub-Saharan Africa to focus on

• br Tanto en el cuerpo principal de la revista como

  2019-07-01

  

  Tanto en el cuerpo principal de la revista como en la sección de análisis de libros y revistas, aparecen artículos y notas de tenor necrológico, los cuales ofrecen una suerte de homenaje póstumo Saikosaponin A personajes que generalmente habían actuado en el terreno científico, filosófico o de ges

• Assim pensamos que os discursos analisados neste

  2019-07-01

  

  Assim, pensamos que os discursos, analisados neste artigo, construídos pelos intelectuais colaboradores de Araucaria de Chile e difundidos pela revista, ao ressaltarem duas vitoriosas revoluções armadas latino-americanas, exatamente no período de vigência da prpm, dialogaram, de alguma maneira, com

• Es as como se establece la relaci n

  2019-07-01

  

  Es así como se establece la relación entre los dos relatos: la novela histórica es parte de la novela policíaca y ambas tienden al mismo fin trágico, la muerte de su respectivo héroe. Al respecto, conviene hacer ciertas acotaciones sobre el término de “héroe”. Si bien en este último pasaje citado de

15874 records 995/1059 page Previous Next First page 上5页 991992993994995 下5页 Last page