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Our analysis revealed that mTOR inhibitors added alone to
2018-10-26
Our analysis revealed that mTOR inhibitors added alone to SF-defined medium can induce mesendoderm, and our follow-up studies confirmed that rapamycin enhances the formation of HE and blood progenitors. Ten-point dose curves revealed a bimodal effect where rapamycin at low concentrations mildly enha
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The ability to use cell surface
2018-10-26
The ability to use cell-surface proteins to specifically sort iPSC-derived hepatocyte-like cells is currently limited. The liver-specific cell-surface protein ASGR1 has been used to sort human ESC- and iPSC-derived hepatocyte-like cells (Basma et al., 2009; Peters et al., 2016). These studies demons
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Much of our knowledge on
2018-10-26
Much of our knowledge on DS comes from the documentation of symptoms in patients and analysis of mouse models. Although the contribution of both sources has been crucial in gaining a better understanding of the syndrome, the molecular pathways leading to the development of DS are still largely unkno
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Global gene expression of RB null teratomas
2018-10-26
Global gene expression of RB1-null teratomas revealed an upregulation of neural-related genes and a depleted expression of epidermal tissue-related genes. As both the nervous system and the epidermis originate from the ectoderm, these results suggest that the RB1 ablation could alter early ectoderma
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In a comparative perspective life
2018-10-26
In a comparative perspective, life expectancy is high in Sweden, meaning that even a mother who gives birth at the very advanced age of 50 would be overwhelmingly likely to still be alive when her child is aged 19. Over 80% of women born in Sweden in the 1940 cohort were still alive by age 70 (Stati
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Grau looks beyond this and affirms
2018-10-26
Grau (2012) looks beyond this and affirms that Spanish universities are not within the actual political priorities of policy makers, and that one of the purposes of the European Commission is for Spanish universities to implement tools of strategic management to become more competitive and responsib
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gap junctions br Theoretical foundation of the study br
2018-10-26
Theoretical foundation of the study Methodology A Web-based survey was distributed to 3060 international and/or general manager in charge of the firm\'s foreign business activity of Spanish exporting firms in the food sector, beverage sector, consumer goods, raw materials, industrial products
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br Combinatorial approach for HEN of variable stream tempera
2018-10-26
Combinatorial approach for HEN of variable stream temperature The paths combination approach developed by Osman et al (Osman et al., 2009) is capable of generating a wider range of HEN retrofit solutions. Nevertheless, some solutions were found to be economically unjustifiable due to the long pay
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Leaching process is one of
2018-10-26
Leaching process is one of the most frequently employed techniques in extractive metallurgy for the recovery of valuable metals using aqueous solutions. Low cost implication, eco-friendly procedure (Habbache et al., 2009), low energy requirement and ability to treat low grade ores (Ajemba and Onukwu
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Anxiety is frequently reported in more
2018-10-26
Anxiety is frequently reported in more than 50% of PD patients [6]. In general, all types of anxiety disorders found in PD are associated with generalized anxiety disorder, agoraphobia, specific phobia, and social anxiety disorder, panic disorder, and obsessive-compulsive disorder or related disorde
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Because of the high impact of biofouling
2018-10-26
Because of the high impact of biofouling on process operation and by implication high economic cost, in recent years there has been an increasing interest in developing an on – line sensor able to monitor biofilm formation in real time, especially in an early stage [7–9]. Despite all the efforts to
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To investigate the electrical properties of
2018-10-26
To investigate the electrical properties of rGO/Al2O3/Au NP FET devices, outputs (drain-source voltage (VDS)=0.1V and gate-source voltage (VGS) from −40V to 40V) were applied into back-gated FET devices under ambient conditions at room temperature. Fig. 3a shows the typical IDS–VG characteristics of
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The influence of the formation
2018-10-26
The influence of the formation of nanograins on the detection of the sensing film can be understood by considering the site-binding model. To illustrate the ionic ep4 receptor procedures at the electrolyte/oxide interface involved in pH sensing, the detecting voltage on the surface potential (ψ) can
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br Materials and methods br Results Microfluidic analytical
2018-10-26
Materials and methods Results Microfluidic analytical devices with optical detection are considered one of the best options for developing robust and sensitive lab-on-chip devices. Key features for diagnostic and prognostic usefulness of such devices are high sensitivity and specificity, abili
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Talabostat mesylate At sea level the majority of animals hav
2018-10-26
At sea level the majority of animals have adapted to breathe air that is composed of 21% oxygen (~21kPa). The normal oxygen level in human Talabostat mesylate is approximately 14kPa [26], which is consumed whilst oxygen is transported throughout the body, via metabolic activity. However, exposure t
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