• During the past three decades platinum based DNA alkylating

  2020-02-03

  

  During the past three decades, platinum-based DNA-alkylating agents have been employed in the treatment of various cancers [14]. Oxaliplatin is currently used as a first-line treatment for colorectal cancer (CRC) [15]. Unfortunately, a large portion of CRC patients receiving oxaliplatin-based chemot

• br Conflicts of interest br Acknowledgments Work in

  2020-02-03

  

  Conflicts of interest Acknowledgments Work in the laboratory of SPS is funded by Council of Scientific and Industrial Research (CSIR) Network Project BSC-0111 (INDEPTH) and BSC-0112 (NanoSHE). We are thankful to Director, CSIR-IITR for his constant encouragement and support. We also acknowledg

• Materials and methods br Results br Discussion Microbial pro

  2020-01-30

  

  Materials and methods Results Discussion Microbial production of trans-4Hyp, an added-value amino azidothymidine mg for pharmaceuticals, offers significant advantages over conventional chemical extraction in economic and environmental aspects. However the low titer and productivity with the

• Both receptors belong to the large family of G

  2020-01-29

  

  Both receptors belong to the large family of G protein-coupled receptors (GPCRs) [4,5], which often appeared as monomers, dimers and higher order aggregates [6,7]. There is evidence that these receptor-complexes can modulate the functionality and the pharmacology of the receptors [8,9] by sequesteri

• br Effects of culture conditions on drug induced

  2020-01-29

  

  Effects of culture conditions on drug-induced gene Sildenafil mesylate sale in primary human hepatocytes Past progress in elucidating the optimal conditions for the long-term cultivation of rodent hepatocytes has helped define some of the key components in the matrix and medium environment that

• We further assessed EBI expression

  2020-01-29

  

  We further assessed EBI2 expression in RRMS patients before and during NTZ treatment. A significant increase of EBI2 expression was observed in memory CD4+ T cell subpopulations, but not in CD8+ T cell or in CD19+ B cell subsets of patients undergoing NTZ treatment, with a parallel gain in the migra

• In all available E E structures the RING type domain

  2020-01-29

  

  In all available E2:E3 structures, the RING-type domain binds the E2 on a surface that is remote from the active site Cys (and therefore from the ubiquitin thioester) (Fig. 2). The non-contiguous E3-binding and active sites on the E2 imply that the role played by a RING to facilitate ubiquitin trans

• In the case of the reaction of

  2020-01-29

  

  In the case of the reaction of 1a with Py2SMeCu(II), compound 4a was observed as the major oxidation product suggesting that further oxidation or hydrolysis of 4a was prevented under our conditions. The precise factors that govern the reactivity and stability of nitrosoamidines remain poorly known.

• br Introduction In mammals there are ten

  2020-01-29

  

  Introduction In mammals there are ten known isoforms of the enzyme diacylglycerol kinase (DGK), as well as gene splice variants. Enzymes of this family all have a homologous active site but differ widely in their molecular mass, mechanisms of activation and biological function (Shulga et al., 201

• The p controls transcription of

  2020-01-29

  

  The p53 controls transcription of several genes that affect the release of cytochrome c in the mitochondrial apoptotic pathway [44]. In addition, p53 can induce a transcription-independent apoptosis through a direct interaction with the Bcl-2 family proteins [45]. However, the role of mitochondrial

• Introduction Cytochrome P CYP A is the most important

  2020-01-29

  

  Introduction Cytochrome P450 (CYP)3A is the most important enzyme involved in the metabolism of 30–40% of currently prescribed drugs [1]. The Minocycline HCl level and activity of CYP3A show large intra- and inter-individual variability, which contributes to unpredictable drug response and toxicity

• The effect of the simple dopaminergic

  2020-01-29

  

  The effect of the simple dopaminergic tonic/phasic model on cognitive processing has been investigated by a few studies (Nolan et al., 2004; Rosa et al., 2010). Rosa et al. (2010), using a Stroop task that requires different levels of cognitive flexibility and stability, observed an association betw

• Furthermore collagen could be further utilized

  2020-01-29

  

  Furthermore, collagen could be further utilized to surface modification of biologically inert materials, such as polymer materials and metal materials, which are always hydrophobic, lacking functional groups and poor cell adhesion. Therefore, various strategies have been tested to improve the prope

• No effect on the A production by secretase was observed

  2020-01-29

  

  No effect on the Aβ production by γ-secretase was observed at 50μM, the highest effective concentration used in cultured bicuculline by the study of Flajolet et al. IC261 did also not exert a modulatory effect on the production of Aβ, Aβ and Aβ species in the cell-free assay at this concentration. γ

• With regards to what might represent a typical

  2020-01-29

  

  With regards to what might represent a typical “baseline” ChE (or AChE) activity in Saccostrea sp., it EHop-016 should be remembered that the observed enzyme responses were obtained in laboratory exposures, over a narrow experimental window (96h), with specimens collected over the course of a week,

15499 records 847/1034 page Previous Next First page 上5页 846847848849850 下5页 Last page