• The differentially expressed proteins during somatic embryog

  2022-01-18

  

  The differentially expressed proteins during somatic embryogenesis are described as the proteins that are induced by oxidative stress and respond to higher cell division activity including ascorbate peroxidase, dehydroascorbate reductase, glutathione transferase and mitochondrial manganese superoxid

• Young et al described the role of adenine monophosphate

  2022-01-18

  

  Young et al. [40] described the role of adenine monophosphate-activated protein kinase (AMPK) in the translocation of GLUT4 in the heart. The AMPK is activated during muscle contraction [74] by converting AMP to ATP. The adenosine analog, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), is a c

• In the second part of this study we

  2022-01-18

  

  In the second part of this study, we investigated the influence of GH on the nf-κb pathway of the ghrelin receptor, GHSR-1a, at the mRNA and peptide levels in cultured whole follicles. Regulation of the expression of GHSR-1a has a key role in the actions of ghrelin in target tissues. Using RT-PCR an

• The general aim of our in vitro experiments was to

  2022-01-18

  

  The general aim of our in vitro experiments was to analyze the patterns of ghrelin and GHSR-1a expression in the mammary glands of dairy goats during pregnancy and to examine the direct effect of ghrelin on cell proliferation in cultured MECs of pregnant dairy goats. For this purpose, we cultured go

• br Materials and methods br Results

  2022-01-18

  

  Materials and methods Results Discussion Acknowledgments This work was financially supported by the University of Tehran, Iran. The authors thank all the teams who worked on the experiments and who provided technical assistance in the laboratory during this study. We also thank the anony

• br Mechanisms of gap junction internalization disaggregation

  2022-01-18

  

  Mechanisms of gap junction internalization: disaggregation, endocytosis and annular gap junctions It has been clearly shown that gap junction internalization can occur by a distinctive mechanism where one cell internalizes an entire gap junction via formation of double membrane structure termed a

• br Results br Discussion In this study we

  2022-01-18

  

  Results Discussion In this study, we investigated the role of galanin and GAL2 receptors on anxiety-like behaviours mediated by the dorsal hippocampus of rats. We showed that locally administered galanin (1 nmol) decreased exploration of the open arms in the EPM, suggesting an anxiogenic-like

• We next investigated whether pharmaceutical inhibition of th

  2022-01-18

  

  We next investigated whether pharmaceutical inhibition of the PI3K pathway was synergistic with FGFR inhibition using BKM120, a pan-PI3K inhibitor with modest antitumor activity in cancer patients, as a single agent. We found that RT112 (- translocation) and JMSU1 ( amplification) were not significa

• br Significance Metabolites present in the extracellular

  2022-01-18

  

  Significance Metabolites present in the extracellular environment can potently modulate cellular phenotypes and potentially serve as therapeutics for various diseases. Ferroptosis is a non-apoptotic cell death process characterized by the generation of toxic lipid reactive oxygen species (ROS). I

• br Introduction More than structurally different isoprenoids

  2022-01-18

  

  Introduction More than 30,000 structurally different isoprenoids, such as steroids, carotenoids, prenyl side-chain of quinones, prenyl proteins, and natural rubber, exist in nature. In a biosynthetic pathway, linear prenyl diphosphates are common structures as a precursor of isoprenoids, as shown

• Overall we partially confirmed our predictions and when

  2022-01-17

  

  Overall, we partially confirmed our predictions, and, when compared to the other existing dataset exploring the interaction among CRFR1, FAAH, and anxiety, our data are somewhat confirmatory. Demers and colleagues (Demers et al., 2016) found one (protective) CRFR1 minor allele (rs110402) and the (le

• Materials and methods br Results

  2022-01-17

  

  Materials and methods Results and discussion Acknowledgments This work was supported in part by the Japan Society for the Promotion of Science KAKENHI Grants JP21300174 and JP25282144 (H.K.). Introduction Epigenetic modifications of histones, such a lysine acetylation, play a key role in

• Interest in the non coding genome has recently surfaced with

  2022-01-17

  

  Interest in the non-coding genome has recently surfaced with accelerated emphasis in the past few years (Li et al., 2016). Transcription factors (TFs) bind to enhancers and mediate RNA initiation from distal transcriptional start sites (TSS) of genes. Epigenome sequencing of human and mouse during d

• br Histamine attenuates the cognitive impairing effects of

  2022-01-17

  

  Histamine attenuates the cognitive impairing effects of early postnatal maternal deprivation Histamine acting on H2 receptors in the hippocampal CA1 region is able to reverse the deleterious effect of the exposure of rats to partial postnatal maternal deprivation on their memory consolidation of

• Cut proteins have five evolutionarily conserved domains Thes

  2022-01-17

  

  Cut proteins have five evolutionarily conserved domains. These include a homeodomain, three Cut repeats, and a coiled coil structure. The cut repeats, called CR1, CR2, and CR3, are composed of 70 amino acids, and, along with the homeodomain, are each capable of binding DNA. Mammalian cut proteins fu

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