• HDAC enzymes oppose the effects of HATs by

  2022-03-14

  

  HDAC enzymes oppose the effects of HATs by reversing lysine acetylation, an action that restores the positive charge of the lysine thus stabilizing the local chromatin structure. By removing acetyl groups from ε-amino lysines of proteins, HDACs not only alter transcription, but also promote either t

• To identify structurally novel autophagy inhibitors a medium

  2022-03-14

  

  To identify structurally novel autophagy inhibitors, a medium throughput screen of our in-house library of approximately 160,000 compounds was performed. In the screening assay, MCF7 NVPBEZ235 stably transfected with eGFP-tagged light chain 3 (LC3), were employed, which can be detected by automated

• Thus one of the aim of the work was to

  2022-03-12

  

  Thus, one of the aim of the work was to link the phytotoxic effect of m-Tyr on root growth of tomato seedlings to modification of RNS level and tissue distribution accompanied by determination of 3-NT content. Due to the role of GSNOR, which is suggested to be a key element in the interplay between

• There is abundant literature about different functional aspe

  2022-03-12

  

  There is abundant literature about different functional aspects of the cannabinoid system (Badal et al., 2017, Balenga et al., 2011, Henderson-Redmond et al., 2016, Nair et al., 2015); however, not a great deal is known about the mechanism by which ethanol impacts its function in connection to the i

• To facilitate the development of novel

  2022-03-12

  

  To facilitate the development of novel diagnostic and therapeutic interventions in NASH, a plethora of animal models have been used to identify molecular targets that are involved in the onset and progression of NASH. In view of recent advances in the understanding of the pathogenesis of NASH and pr

• The original Bee Synch methodology now termed Bee Synch I

  2022-03-12

  

  The original Bee Synch methodology (now termed Bee Synch I) utilizes a 5-day CIDR, GnRH (GnRH-1) and PGF on day 0, double dose of PGF on day 5, and FTAI with GnRH (GnRH-2) at 66 h after CIDR removal. Cruppe et al. (2014) reported that the inclusion of GnRH on day 0 does not contribute appreciably to

• br Acknowledgments This research was supported by a grant fr

  2022-03-12

  

  Acknowledgments This research was supported by a grant from the Korea Health Technology R&D Project through the Korean Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (grant number: HI17C0616). Dr. Jun-Mo Yang was supported by the Natio

• br Introduction Glucose is the major

  2022-03-12

  

  Introduction Glucose is the major carbon source in most organisms. Cancer Sitafloxacin in particular require a steady source of energy to maintain growth and proliferation, and preferentially use glycolysis for their energy supply even under aerobic conditions. Glucose uptake in mammals is mainly

• br Methods br Results and

  2022-03-12

  

  Methods Results and discussion Conclusions A third example of a hexokinase using polyphosphate exclusively as a phosphoryl donor has been identified, this time in mammalian tissues. This is the first polyphosphate utilizing enzyme activity demonstrated in mammalian NCT-503 as far as we are

• The usefulness of GIP R antagonism for the treatment of

  2022-03-12

  

  The usefulness of GIP-R antagonism for the treatment of obesity-diabetes has been revealed in numerous studies employing knockout or chemical blockade of GIP-R signalling.*88, 89, *90, 91, 92, 93, 94, 95, 96, *97 For example, sub-chronic daily administration of (Pro3)GIP to ob/ob mice results in sig

• The gene structures of cGalR and cGalR L were

  2022-03-12

  

  The gene structures of cGalR2 and cGalR2-L were determined by in silico comparison with the chicken genomic DNA sequences retrieved from the Ensembl database. Both cGalR2 and cGalR2-L genes are composed of two coding exons, separated by single introns of 0.9kb (cGalR2) or 3kb (cGalR2-L) locating wit

• Bile acids BAs are critical for facilitating the absorption

  2022-03-12

  

  Bile acids (BAs) are critical for facilitating the hyPerFUsion™ high-fidelity PCR Kit sale of dietary lipids and lipid-soluble vitamins in the intestines [6], [7]. At physiological levels, BAs function as signaling molecules and activate specific nuclear receptors [farnesoid X receptor (FXR), pregn

• Receptor interactions and binding mode of in

  2022-03-12

  

  Receptor interactions and binding mode of in hGPR40 were determined by docking studies. The compound was docked in the rebuilt co-crystal structure of hGPR40 (PDB ID: ) using MOE for loop modeling and energy minimization and Glide for molecular docking. The docking site used for the docking simulati

• Several transgenic and knockout congenic mouse models have b

  2022-03-12

  

  Several transgenic and knockout/congenic mouse models have been generated in order to assess the role of FFAR1 for proper insulin secretion and maintenance of glucose homeostasis. The results obtained with three different receptor knockout mouse models were not consistent. The protection against hig

• We compared the mixotrophic growth of mutant DRHB and the

  2022-03-12

  

  We compared the mixotrophic growth of mutant DRHB1486 and the wild-type at different light intensities. The mutant grew at a similar rate as the wild-type at a low light intensity but much more slowly at a high light intensity (Fig. 3). Because the slr2094 mutant was unable to grow under photoautotr

15546 records 438/1037 page Previous Next First page 上5页 436437438439440 下5页 Last page