• H R antagonism can prevent seizure development and improve w

  2022-06-22

  

  H3R antagonism can prevent seizure development and improve working memory through the activation of histaminergic neurons (Huang et al., 2004, Zhang et al., 2003). In addition, we have recently found that H3R antagonism protects against ischemia-reperfusion injury via histamine-independent mechanism

• br Introduction Chronic hepatitis C CHC caused by hepatitis

  2022-06-22

  

  Introduction Chronic hepatitis C (CHC) caused by hepatitis C virus (HCV) infection affects approximately 170 million individuals worldwide [1]. HCV and human immunodeficiency virus (HIV) have similar routes of transmission, including blood-to-blood contact, sharing of injection equipment, and sex

• Overall more males were HCV mono and co infected though

  2022-06-22

  

  Overall, more males were HCV mono- and co-infected, though there was no significant age difference among groups and between men and women (all p>0.05). Almost all patients included in this study were over 40 years, in line with the period in which no HCV screening was performed in Brazilian blood b

• br Conclusion The following is the supplementary data relate

  2022-06-22

  

  Conclusion The following is the supplementary data related to this article. Conflict of interest Funding Acknowledgements Peroxiredoxin VI (Prdx6) is a dual-functioning antioxidant enzyme that acts to protect biological membranes against damage caused by lipid peroxidation , . The enz

• Introduction Epigenetic alterations play an important role i

  2022-06-22

  

  Introduction Epigenetic alterations play an important role in carcinogenesis. Aberrant promoter CpG island hypermethylation causes transcriptional gene silencing [1], and has been documented for a number of genes in prostate cancer (PCA) [2]. Histone modifications are also important regulators of t

• Also in this work we investigated

  2022-06-22

  

  Also in this work, we investigated the correlated signaling pathways of GSK-3 inhibition in protecting bupivacaine-induced DRG neurotoxicity. Through western blot assay, we demonstrated that, SB216763 suppressed protein productions of p-GSK-3 α/β and Casp-3, but increased protein production of PKC,

• The finding that GPR acts as a receptor for acyl

  2022-06-21

  

  The finding that GPR35 acts as a receptor for 2-acyl LPA is noteworthy, because P2Y5, which has homology with GPR35 (29%), has recently been shown to act as a receptor for 2-acyl LPA [14]. LPA3 is also a specific receptor for 2-acyl LPA [15]. It is also worth noting that GPR55, which has homology wi

• Limited efforts were made to exploit the naturally occurring

  2022-06-21

  

  Limited efforts were made to exploit the naturally-occurring antigen-specific Treg for ex vivo expansion. This study sets up a reproducible protocol for the expansion of insulin-specific Treg isolated from NOD mice. These favipiravir exhibited higher suppressive capacity compared to the polyclonal T

• br Acknowledgments br Introduction When human red blood

  2022-06-21

  

  Acknowledgments Introduction When human red blood cell (hRBC) membranes are depolarized, either as intact PF-8380 suspended in depolarizing (low Cl−) Ringers or under voltage clamp conditions using excised inside-out patches, they respond by opening a nonselective voltage-dependent cation (NSV

• Bile acids BAs are critical for facilitating

  2022-06-21

  

  Bile acids (BAs) are critical for facilitating the Vinorelbine ditartrate of dietary lipids and lipid-soluble vitamins in the intestines [6], [7]. At physiological levels, BAs function as signaling molecules and activate specific nuclear receptors [farnesoid X receptor (FXR), pregnane X receptor, a

• Consistent with our gene profiling analyses showing that gen

  2022-06-21

  

  Consistent with our gene-profiling analyses showing that genes involved in mutual compensation of EGFR or integrin/FAK were significantly downregulated by Tinagl1 overexpression, treatment with r-Tinagl1 inhibited the activation of EGFR and FAK in vitro, and phenocopied the combined inhibition of in

• Two recently developed highly specific EZH enzymatic inhibit

  2022-06-21

  

  Two recently developed, highly specific EZH2 enzymatic inhibitors, GSK126 and EPZ-6438, are currently in clinical trials for treating lymphomas (Kim and Roberts, 2016). Although these EZH2 inhibitors have shown antitumor effects in lymphoma cells with enzyme-activating mutations of EZH2 (Knutson et 

• Over the last decade intense efforts

  2022-06-20

  

  Over the last decade, intense efforts have been devoted toward identifying IN inhibitors as potential drugs against HIV. Raltegravir and elvitegravir are integrase strand transfer inhibitors (INSTIs) that have been approved for therapy and dolutegravir is another INSTI that is currently in advanced

• br Heme oxygenase inhibitors Historically the first

  2022-06-20

  

  Heme oxygenase-1 inhibitors Historically, the first class of competitive HO-1 inhibitors was represented by MPs, heme analogs in which the central iron tankyrase of heme is exchanged by another element, such as zinc, cobalt, tin, or chromium. These molecules compete with heme for binding to the

• Introduction Soluble guanylyl cyclase sGC is a key protein

  2022-06-20

  

  Introduction Soluble guanylyl cyclase (sGC) is a key protein in the regulation of multiple physiological functions in mammalian physiology [1,2]. Upon stimulation by nitric oxide (NO) [3], sGC generates cyclic guanosine monophosphate (cGMP) from guanosine-5′ triphosphate and activates protein kina

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