• Hepatitis C virus HCV is a frequent cause of infectious

  2022-06-28

  

  Hepatitis C virus (HCV) is a frequent cause of infectious chronic hepatitis. Unlike hepatitis A and B, there is no vaccine to prevent hepatitis C infection yet. According to WHO, around 200 million people are infected with HCV worldwide [1], in addition to three to four million newly infected patien

• Curcumin is a major yellow

  2022-06-28

  

  Curcumin is a major yellow pigment in turmeric ground rhizome of Curcuma longa Linn, which is used widely as a spice and coloring agent in several foods such as curry, mustard and potato chips as well as cosmetics and drugs (Okada et al., 2001, Joe et al., 2004). Curcumin represents a class of anti-

• Receptor guanylyl cyclases play essential roles in cardiovas

  2022-06-28

  

  Receptor guanylyl cyclases play essential roles in cardiovascular and gastrointestinal (patho-)physiology, reproduction biology, cell proliferation, bone growth and sensory signal transduction and, therefore, are important pharmacological targets. Accordingly, the receptor guanylyl cyclase agonists

• Cells undergoing EMT display a downregulation of E cadherin

  2022-06-28

  

  Cells undergoing EMT display a downregulation of E-cadherin and dissociation of their junctional complexes that associates cell-cell contacts with the 4112 cytoskeleton, known as the adherens junction (Berx and van Roy, 2009, Birchmeier and Behrens, 1994). Adherens junctions are specialized cell-ce

• Also in this work we investigated the correlated signaling p

  2022-06-28

  

  Also in this work, we investigated the correlated signaling pathways of GSK-3 inhibition in protecting bupivacaine-induced DRG neurotoxicity. Through western blot assay, we demonstrated that, SB216763 suppressed protein productions of p-GSK-3 α/β and Casp-3, but increased protein production of PKC,

• br Positive regulation of gene expression by Nrf br

  2022-06-28

  

  Positive regulation of gene Puromycin receptor by Nrf2 Repression of Nrf2 by Keap1 Because many xenobiotic inducers of NQO1 and GST enzyme activities contain a thiol-reactive electrophilic moiety (i.e. are soft electrophiles), Paul Talalay and colleagues predicted in 1988 that they would be r

• Furthermore increased plasma levels of endoglin have been as

  2022-06-28

  

  Furthermore, increased plasma levels of endoglin have been associated with diabetic complications (Valbuena-Diez et al., 2012). The involvement of soluble endoglin in a number of widespread pathologies demonstrates that endoglin is not only marker of endothelial integrity but also a causative factor

• br Manganese based imaging probes br Imaging of vesicular mo

  2022-06-28

  

  Manganese-based imaging probes Imaging of vesicular monoamine transporter 2 (VMAT2) Imaging of sulfonylurea receptor 1 (SUR1) In mammals, insulin secretion is mediated by the membrane potential of pancreatic β-cells. Increases in glucose levels lead to blocking of ATP-sensitive potassium ch

• br Pharmacology br Background to GPR function br The emergin

  2022-06-28

  

  Pharmacology Background to GPR35 function The emerging function of GPR35 in the nervous system Conclusions The role of GPR35 in the modulation of synaptic transmission, neurogenic and inflammatory pain, and potential signalling pathways involved in these processes are beginning to emerge

• br STAR Methods br Acknowledgments This

  2022-06-28

  

  STAR★Methods Acknowledgments This work was supported by the American Diabetes Association (grant 1-12-BS-161 to J.D.P.), an NIH predoctoral T32 in Autoimmunity and Immunopathology grant (AI089443-05 to D.M.P.), the NIH (grant DK099550 to H.M.T.), the American Association for Cancer Research (S

• As discussed above both endogenous and exogenous

  2022-06-28

  

  As discussed above, both endogenous and exogenous lesions can lead to adverse health effects [43]. Damaged nucleobases can block DNA replication which is often lethal to cells [44]. The effectiveness of DNA restoration by DNA glycosylases should be closely monitored to gain an insight of the functio

• APETx2 In conclusion we demonstrated that the atypical high

  2022-06-28

  

  In conclusion, we demonstrated that the atypical high-basal activity of the mGlu3 APETx2 results mostly from its activation by low ambient glutamate concentrations. This is due to a unique interaction network located in the extracellular domain of the mGlu3 receptor. This network acts as “Cl− lock”

• Long non coding RNAs lncRNAs are mRNA

  2022-06-28

  

  Long non-coding RNAs (lncRNAs) are mRNA-like transcripts of greater than 200 nucleotides (nt), with little or no protein-coding potential [13,14]. LncRNAs have been suggested to participate in transcription and post-transcription regulation as scaffolds, guides, decoys or repressors, activators, and

• br Acknowledgments br Introduction Non steroidal anti inflam

  2022-06-27

  

  Acknowledgments Introduction Non-steroidal anti-inflammatory drugs (NSAIDs) are a common treatment for a number of disease states involving an inflammatory reaction. This group of drugs mediate their anti-inflammatory effects mainly by inhibition of cyclooxygenase (COX), an enzyme of prime imp

• FPR family Human FPR was first defined biochemically in

  2022-06-27

  

  FPR family Human FPR was first defined biochemically, in 1976, as a high affinity binding site on the surface of neutrophils for the prototypic N-formyl peptide formyl-methionine-leucyl-phenylalanine (fMLF). It was then cloned in 1990, by Boulay et al. from a differentiated HL-60 myeloid leukemia-c

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