• Moreover a multiple regression analysis using the year

  2023-09-12

  

  Moreover, a multiple regression analysis using the 1-year MMSE score as a dependent variable was conducted. The result showed that serum resulted in levels at admission did not affect the MMSE score 1 year later (β = 0.10, p = 0.639). Discussion In this study, serum Aβ42 levels were significant

• We found that decreased Ng levels lead to

  2023-09-12

  

  We found that decreased Ng levels lead to a lower threshold for LTD induction at L4–L2/3 synapses. Previous studies in hippocampal slice culture have shown that LTD at individual synapses induces spine elimination at both the targeted synapse and selective neighboring synapses when spines are monito

• In glaucoma the primary retinal defect appears

  2023-09-12

  

  In glaucoma, the primary retinal defect appears in the GCL, whereas the other retinal layers appear normal (Kendell et al., 1995). In the current work, chronic elevation of IOP induced RGC apoptosis, especially in the GCL, and α2 adrenergic treatment reduced RGC apoptosis. Various studies have repor

• br Methodology In this paper mechanical properties of G

  2023-09-12

  

  Methodology In this paper, mechanical properties of G-actin are examined. To do so, three different external tensile loads are exerted to the protein. As illustrated in Fig. 1, Arp2/3 complex binds to the one sides of mother Adenosine-5'-diphosphate and leads to the growth of a new daughter fila

• Considering the physicochemical stability results

  2023-09-12

  

  Considering the physicochemical stability results on Fig. 5, it was observed that the particles are stable when they are stored at 4 °C for 30 days. After day 30, a significant increase was observed in particle size, but at the end of the 90 days the SLN particle size is still below 100 nm. Stabilit

• The link between HPV infection and neoplasia

  2023-09-12

  

  The link between HPV infection and neoplasia has been well established. HPV encodes two oncogenes (E6 and E7) that drive Phusion high-fidelity DNA polymerase mg progression by controlling the functions of tumor suppressor proteins p53 and Rb [7]. HPV is associated with more than 99% of cervical CES

• Introduction Mitotic kinases play an

  2023-09-12

  

  Introduction Mitotic kinases play an essential role in mitosis, Aurora and other mitotic kinases are often observed over-expression in human solid and many hematologic cancers. As one of serine/threonine kinases, Aurora kinase family is involved in centrosome maturation, mitotic spindle formation,

• As aforementioned this study aimed to design synthesize

  2023-09-12

  

  As aforementioned, this study aimed to design, synthesize and investigate aromatase inhibitory and anti-breast cancer activities of N,N′-disubstituted thiourea derivatives. Based on the attractive phenotypic molecule 1, the synthetic N,N′-disubstituted thioureas have been designed including monothio

• br Acknowledgments This study is a part of a MSc

  2023-09-12

  

  Acknowledgments This study is a part of a MSc thesis and supported by Scientific Research Projects Coordination Unit of Akdeniz University (grant number: 2011.02.0122.007). Introduction Apelin receptor (putative receptor protein related to the angiotensin receptor AT1, APJ) belongs to the G-p

• br Apelin The APJ receptor ligand

  2023-09-12

  

  Apelin The APJ receptor ligand apelin firstly in 1998 was segregated from bovine stomach tissue. Human preproapelin gene located on chromosome Xq25–26.1. The apelin preproproteins consist of 77 amino NT157 australia residues that are cleaved into biologically active C-terminal fragments of vario

• br The role of apelin in

  2023-09-12

  

  The role of apelin in hepatic diseases The involvement of the apelin/APJ system in liver physiology and pathology has been proven in numerous studies (Table 6). For instance, in the experiment of Emam et al. [63] on rats suffering from hepatic injury, apelin decreased the levels of ALT, AST and L

• The alamarBlue test revealed that recombinant apelin led to

  2023-09-12

  

  The alamarBlue test revealed that recombinant apelin led to an increase in basal and IGF1- and FHS-induced ovarian cell proliferation. Apelin increased ERK1/2 and Akt protein expression, but cell proliferation returned to control levels in the presence of kinase inhibitors. This suggests that the pr

• br Introduction The apelin receptor angiotensin receptor lik

  2023-09-12

  

  Introduction The apelin receptor (angiotensin receptor-like 1, APJ) is a seven transmembrane receptor (7TMR) that belongs to the class A peptidergic G protein-coupled receptors (GPCR) superfamily [1]. The endogenous ligands of APJ are the different isoforms of apelin (namely apelin-13, −17, and −

• br Introduction Nonalcoholic fatty liver disease

  2023-09-11

  

  Introduction Nonalcoholic fatty liver disease (NAFLD) is a clinicopathologic spectrum of liver pathologies associated with excessive accumulation of fat in the liver. This spectrum is continuous but can be graded based on pathological features; in increasing severity, these are: bland steatosis,

• In conclusion phenolic hydroxyl was introduced not

  2023-09-11

  

  In conclusion, phenolic hydroxyl was introduced not only to C3 side chain but also to C6 or C7 position of the quinoxalinone core, resulting in a new group of ARIs candidates exhibiting antioxidant activity. Biological activity tests suggested that compounds were not only sufficient to inhibit ALR2

15874 records 274/1059 page Previous Next First page 上5页 271272273274275 下5页 Last page