• For the derivatives a c

  2025-02-05

  

  For the derivatives 3a–3c, another likely explanation for antifungal properties is that polymers bearing primary amine groups and secondary phosphoryl groups formed, enhancing complexation with the phosphate groups, and the complexes are amphiphilic (Palermo, Lee, Ramamoorthy, & Kuroda, 2011). The a

• On the other hand oxygen concentration in tumor

  2025-02-05

  

  On the other hand, oxygen concentration in tumor tissue also depends on its consumption rate by tumor cells, which decrease will also lead to alleviation of hypoxia. This fact is not taken into account in the majority of studies on the topic, although it is well-known that antiangiogenic therapy doe

• br AR expression in breast tissue

  2025-02-05

  

  AR expression in breast tissue Although androgenic signalling is chiefly associated with the development and maintenance of primary and secondary male characteristics, especially during puberty when the testes are by far the major source of testosterone, the AR also plays important functions in f

• Linagliptin is a recently approved dipeptidyl peptidase

  2025-02-05

  

  Linagliptin is a recently approved dipeptidyl peptidase-4 (DPP-4) inhibitor and widely considered as first-line treatment for patients with type 2 diabetes. DPP-4 is responsible for the inactivation of incretin hormones, such as glucagon-like peptide 1 (GLP-1). GLP-1 is released by the intestine aft

• myosin The reactions and the control mechanisms

  2025-02-05

  

  The reactions and the control mechanisms described are all supported by observations. For example the reactions require that different compounds are formed in different groups of myosin cells and this has been observed [15]. Intravenous injection of glycine results in reduced utilisation of glucose

• br Impact of global AHR deficiency on

  2025-02-05

  

  Impact of global AHR deficiency on diet-induced obesity Two subsequent studies in which AHR function was affected at the whole animal level corroborated the role of AHR in dietary obesity. Xu et al. [14] showed that on a high-fat diet, both AHR-deficient Ahr−/− and hemizygous Ahr+/− mice gained s

• The cavity volume of the binding pocket may

  2025-02-05

  

  The cavity volume of the binding pocket may differ not only between species but also among various AhR/ARNT isoforms within a single species. It is noteworthy that even a single amino GSK343 substitution within a binding pocket may result in a change in the cavity volume. This, in turn, may affect

• br Materials and methods br

  2025-02-05

  

  Materials and methods Results Discussion In this study, we have demonstrated that the adiponectin system (genes and proteins) is present in the porcine endometrium (epithelial glandular cells, luminal epithelial Fomepizole receptor and stromal cells) and myometrium (longitudinal and circul

• Although the role of mossy fiber

  2025-02-05

  

  Although the role of mossy fiber sprouting in epileptogenesis has been challenged (Elmer et al., 1997, Nissinen et al., 2001), in addition to astrogliosis, mossy fiber sprouting is one of the characteristic histopathological findings in TLE (Kharatishvili et al., 2006, Pitkanen et al., 2007, Represa

• br Results br Discussion To achieve quantitative understandi

  2025-02-05

  

  Results Discussion To achieve quantitative understanding of Cyanine3.5 fluorescent dye turnover, we utilize rapidly moving lamellipodial fragments that are geometrically simple, structurally homogeneous, and persistent, and measure relevant rates and concentrations in this system. We find tha

• Genetic observations from these studies suggest that

  2025-02-05

  

  Genetic observations from these studies suggest that GMF regulates Arp2/3 complex and Angiotensin 1/2 (1-7) amide sale dynamics in vivo13, 14. Budding yeast Gmf1 localizes to cortical actin patches, sites of endocytosis assembled by Arp2/3 13, 14. Furthermore, deletion of GMF1 exacerbates the growth

• At the last follow up

  2025-02-05

  

  At the last follow-up, nine patients had discontinued pyridostigmine within the first year postoperatively. Only one patient required pyridostigmine at a higher dose, but this was accompanied by successful weaning of prednisolone. None of the 5 patients who were on pyridostigmine treatment alone pri

• chpg Previously we reported that EL Kras mice

  2025-02-05

  

  Previously, we reported that EL-Kras mice-fed diets rich in omega-6 FAs demonstrated increased pancreatic mast cell infiltration [16]. Significantly, increased infiltration of mast cells into the tumor microenvironment correlates with a poor prognosis [15]. Soucek et al.[25] demonstrated that mast c

• Beside estrogen several classes of compounds have shown

  2025-02-03

  

  Beside estrogen, several palmitic acid of compounds have shown significant neuroprotective efficacy when administered shortly after the induction of animal models of stroke, including glutamate (NMDA) receptor antagonists and zinc chelators [25], [26], [27]. Effects of these or other neuroprotectiv

• We also found that the size

  2025-02-01

  

  We also found that the size of mEPSC amplitude was reduced in unc-43 mutants, consistent with the decrease in synaptic GLR-1/GLR-2 heteromeric receptors. The decrease in mEPSC amplitude was not as great as that observed when measuring current in response to pressure application of glutamate. These d

15853 records 16/1057 page Previous Next First page 上5页 1617181920 下5页 Last page