Several studies have reported the existence of rare CD

2018-10-20

Several studies have reported the existence of rare CD34− HSCs upstream of the major population of CD34+ HSCs in the human hematopoietic hierarchy (Anjos-Afonso et al., 2013; Bhatia et al., 1998). Interestingly, the first HSCs found in the human embryo are CD34+ and give rise exclusively to a CD34+C

A variety of suitable murine xenograft models are currently

2018-10-20

A variety of suitable murine xenograft models are currently used in hematopoietic research, yet these animals require conditioning prior to experimentation. Given the increasingly restricted access to radiation sources, NBSGW mice are broadly enabling, allowing laboratories without access to radiati

It is intriguing that all surviving germ cells

2018-10-20

It is intriguing that all surviving germ cells in Ret mutant mice expressed GFRA1. It is possible that GFRA1 was upregulated to compensate for the reduction of GDNF signaling. Because of the controversy on GFRA1 expression on SSCs, we performed FACS experiments to explore the relationship between GF

The pleiotropic nature of FGF and

2018-10-20

The pleiotropic nature of FGF2 and its variety of downstream effects make generation of highly pure active protein essential. Heparin chromatography has been used for purification of 18kDa FGF2 isoform. However, subsequent heparin contamination in purified FGF2 preparations has been previously descr

The genomic stability of hIPSCs has been

2018-10-20

The genomic stability of hIPSCs has been extensively studied since this could be a major limitation for clinical applications (Aasen et al., 2008). Factors that affect the genomic integrity of stem SRT1720 include culture conditions, number of passages, and enzymatic and non-enzymatic dissociation

order Cy3.5 hydrazide br Results br Discussion Although cell

2018-10-20

Results Discussion Although cell therapy is a promising approach for treating enteric neuropathies, it is commonly thought that enteric neural progenitors isolated from the human bowel will require biological and/or genetic manipulation prior to transplantation, owing to the size of the human

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2018-07-29